Clinical, radiological, and anatomopathological characteristics of patients with atypical teratoid rhabdoid tumor at a national pediatric referral center in Lima, Peru
DOI:
https://doi.org/10.59594/iicqp.2026.v4n1.161Keywords:
Teratoid Tumor, Central Nervous System Neoplasms, Pediatrics, Immunohistochemistry, Diagnostic ImagingAbstract
Objective: To describe the clinical, radiological, and anatomopathological characteristics of patients diagnosed with atypical teratoid rhabdoid tumor (ATRT) treated at a national referral center in Lima, Peru.
Methods: Patients aged < 18 years diagnosed with ATRT and treated at the Instituto Nacional de Salud del Niño San Borja between 2017 and 2024 were included. Sociodemographic data, clinical manifestations, immunohistochemical findings, and computed tomography and magnetic resonance imaging findings at diagnosis were collected from medical records. Data analysis was performed using Microsoft Excel version 16.104.
Results: Fourteen patients were included, aged between 7 months and 12 years, with a predominance of males. The most frequent clinical manifestation was vomiting (85.7%), followed by hydrocephalus. The predominant tumor location was supratentorial (57.1%), followed by infratentorial and spinal locations. Imaging studies showed variable radiological presentations. Diagnosis was confirmed by immunohistochemistry in all cases, demonstrating loss of nuclear INI1 expression, and rhabdoid cells were identified in most cases (64.3%).
Conclusions: In our cohort, ATRTs showed variable clinical and radiological presentations. This study contributes to the characterization of this rare neoplasm in the national context.
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